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October 1, 1967CirculationOpen Access

In patients with pure mitral stenosis, low maximal oxygen uptake defined the reduction in stroke volume, while other circulatory responses were normal with respect to relative oxygen uptake.

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Population

7 patients with "pure" mitral stenosis

Design

Cross-sectional

Key result

In patients with pure mitral stenosis, low maximal oxygen uptake defined the reduction in stroke volume, while other circulatory responses were normal with respect to relative oxygen uptake.

Authors

JBJohn R. BlackmonLRL. B. RowellJKJohn W. Kennedy

Discussion

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Overview

May inform exercise testing interpretation in mitral stenosis; leaves open clinical utility and requires prospective validation.

Study Design

Type

Observational (n=7)

Structured PICO

P
Population
7 patients with "pure" mitral stenosis undergoing mild through maximal upright exercise testing.
E
Exposure
Mild through maximal upright exercise
O
Outcome
Maximal oxygen uptake and acute circulatory and respiratory adjustments (including cardiac output, hepatic clearance of indocyanine green, A-V oxygen difference, heart rate, blood lactate, and ventilation)surrogate

In patients with pure mitral stenosis, the reduction in stroke volume is defined by low maximal oxygen uptake, whereas other circulatory responses remain normal when adjusted for relative oxygen uptake.

Cite This Study

Blackmon et al. (1967) conducted an observational in Mitral stenosis (n=7). Mild through maximal upright exercise was evaluated on Circulatory and respiratory adjustments (cardiac output, A-V oxygen difference, heart rate, blood lactate, ventilation). In patients with pure mitral stenosis, low maximal oxygen uptake defined the reduction in stroke volume, while other circulatory responses were normal with respect to relative oxygen uptake.

synapsesocial.com/papers/6a217c2696850e9b858b7cb5https://doi.org/10.1161/01.cir.36.4.497
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