Orthostatic Hypotension as a Risk Factor for Incident Heart Failure
Key result
Orthostatic hypotension was associated with an increased risk of incident heart failure over 17.5 years of follow-up (HR 1.54; 95% CI 1.30-1.82), particularly in individuals aged ≤55 years.
Why the study?
Is orthostatic hypotension a risk factor for incident heart failure in adults free of prevalent heart failure?
Population
12,363 adults free of prevalent heart failure with baseline orthostatic measurements from the…
Comparison
Orthostatic hypotension vs Absence of orthostatic hypotension
Design
Cohort
Follow-up
17.5 years
Authors
Discussion
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Member takes
Implication
Should not yet change practice; leaves open whether orthostatic hypotension screening identifies modifiable targets for heart failure prevention.
Study Design
Type
Cohort (n=12,363)
Multicenter
Yes
Structured PICO
Is orthostatic hypotension a risk factor for incident heart failure in adults free of prevalent heart failure?
P
Population
12,363 adults free of prevalent heart failure with baseline orthostatic measurements, followed for 17.5 years.
E
Exposure
Orthostatic hypotension (decrease of systolic blood pressure ≥20 mmHg or diastolic blood pressure ≥10 mmHg with position change from supine to standing)
C
Comparator
Absence of orthostatic hypotension
O
Outcome
Incident heart failure (identified from hospitalization or death certificate disease codes)hard clinical
Main Result
Hazard Ratio: 1.54 (95% CI 1.3–1.82)
Orthostatic hypotension is an independent predictor of incident heart failure among middle-aged individuals, particularly those 45 to 55 years of age.
Cite This Study
Jones et al. (2012) conducted a cohort in Incident heart failure (n=12,363). Orthostatic hypotension vs. No orthostatic hypotension was evaluated on Incident heart failure (HR 1.54, 95% CI 1.30-1.82). Orthostatic hypotension was associated with an increased risk of incident heart failure over 17.5 years of follow-up (HR 1.54; 95% CI 1.30-1.82), particularly in individuals aged ≤55 years.