Key result
Vitamin D3 replacement therapy improved the frequency of angina and exercise duration in patients with cardiac syndrome X and vitamin D deficiency.
Why the study?
Does intramuscular vitamin D3 replacement improve angina and exercise-induced ischemia in patients with cardiac syndrome X and vitamin D deficiency?
Does intramuscular vitamin D3 replacement improve angina and exercise-induced ischemia in patients with cardiac syndrome X and vitamin D deficiency?
Vitamin D replacement therapy in patients with cardiac syndrome X and vitamin D deficiency significantly improves angina frequency and objective signs of exercise-induced ischemia.
Answers are grounded in this paper and cite their sources.
May support vitamin D replacement in deficient cardiac syndrome X patients; hypothesis-generating, requires RCTs before practice change.
Aims: The aim of present study was to assess whether vitamin D, with proven beneficial effects on the cardiovascular system, has any effect on angina and exercise-induced ischemia in patients with cardiac syndrome X and low serum vitamin D. Methods: Patients with cardiac syndrome X and low serum vitamin D3 were studied before and after treatment with an intramuscular injection of vitamin D3 (300,000 units, every other week for 2 months). We determined the angina episode (per day) and several indices of exercise capacity. Results: At the end of the treatment course (75±6 day), a significant increase of serum vitamin D3 occurred and was within the normal range (45±8 ng/ml) and the frequency of angina improved significantly ( p=0.003). Exercise duration and maximal work capacity increased significantly ( p<0.001). Maximal ST-segment depression (mm) decreased significantly ( p=0.001). The calculated Duck treadmill score improved significantly ( p=0.001). Conclusions: Our findings show that vitamin D replacement therapy in patients with cardiac syndrome X and vitamin D deficiency dramatically improves symptoms and signs of ischemia.
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Andishmand et al. (2014) studied Cardiac syndrome X and vitamin D deficiency. Vitamin D3 vs. Baseline (pre-treatment) was evaluated on Frequency of angina and indices of exercise capacity (p=0.003). Vitamin D3 replacement therapy improved the frequency of angina and exercise duration in patients with cardiac syndrome X and vitamin D deficiency.
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