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This research aims to develop new fungicidal agents for effectively treating wheat scab caused by Fusarium graminearum.

Novel Camphor Sulfonohydrazide and Sulfonamide Derivatives as Potential Succinate Dehydrogenase Inhibitors against Phytopathogenic Fungi/Oomycetes

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Randomized trial demonstrates potent antifungal activity in wheat scab treatment, suggesting new agrochemical development.

This research aims to develop new fungicidal agents for effectively treating wheat scab caused by Fusarium graminearum.
Designed and synthesized 39 camphor sulfonohydrazide/sulfonamide derivatives.
Conducted in vitro antifungal assays to assess compound efficacy against various fungi.
Utilized molecular dynamics simulations and docking studies to analyze interactions with succinate dehydrogenase.
Compound 4n showed the best activity against Fusarium graminearum with an EC50 of 0.41 mg/L.
4n exhibited potent SDH inhibitory activity with an IC50 of 3.94 μM, comparable to pydiflumetofen.
4n significantly increased cell membrane permeability and damaged fungal cell structures.

Yang et al. (2022) studied this question.

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