Key result
Angiotensin II reduced junctional conductance by about 55% within 20 seconds, whereas enalapril increased junctional conductance by 106% within 2 minutes in isolated rat ventricular cell pairs.
Why the study?
Does modulation of the renin-angiotensin system alter junctional conductance in isolated adult rat ventricular cell pairs?
Population
Isolated ventricular cell pairs of adult rats
Design
Preclinical
Authors
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May link enalapril to improved myocyte coupling; leaves open clinical antiarrhythmic relevance.
Does modulation of the renin-angiotensin system alter junctional conductance in isolated adult rat ventricular cell pairs?
Inhibition of the renin-angiotensin system with enalapril increases electrical coupling between cardiac myocytes, providing a potential cellular mechanism for its antiarrhythmic and heart failure benefits.
Mello et al. (1992) studied this question. Angiotensin II and Enalapril was evaluated on Junctional conductance (gj). Angiotensin II reduced junctional conductance by about 55% within 20 seconds, whereas enalapril increased junctional conductance by 106% within 2 minutes in isolated rat ventricular cell pairs.
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