Key result
Intracellular renin reduces junctional conductance ~29%, an effect blunted by enalaprilat and enhanced by angiotensinogen.
Population
Cell pairs isolated from adult rat ventricle
Design
Preclinical
Follow-up
7 minutes
Authors
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Intracrine renin-angiotensin effects on gap junctions remain hypothesis-generating in rats; human relevance and therapeutic implications require further study.
p-value: p=< .05
Intracellular renin and angiotensinogen decrease junctional conductance in ventricular cell pairs, suggesting that an intracrine renin-angiotensin system regulates intercellular communication in the heart.
Walmor C. De Mello (1995) studied this question. Intracellular dialysis of renin was evaluated on junctional conductance (p=< .05). Intracellular dialysis of renin decreased junctional conductance by 29% in 7 minutes (P < .05), an effect that was reduced by enalaprilat and enhanced by angiotensinogen.
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