Key result
Enalapril (1 micrograms/ml) increased junctional conductance in isolated rat heart cell pairs by 106% within 4 minutes, an effect not suppressed by propranolol.
Why the study?
Does enalapril or angiotensin II alter junctional conductance in isolated rat heart cell pairs?
Population
Isolated rat heart cell pairs (n=20)
Design
Preclinical
Follow-up
4 min
Authors
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These rat data warrant targeted human studies on gap junction modulation; should not alter current enalapril use.
Does enalapril or angiotensin II alter junctional conductance in isolated rat heart cell pairs?
Effect estimate: 106 +/- 3.1% increase
Enalapril increases and angiotensin II decreases junctional conductance in isolated rat heart cells, suggesting an intrinsic cardiac renin-angiotensin system regulates gap junctions.
Mello et al. (1991) studied Isolated rat heart cell pairs (n=20). Enalapril was evaluated on Junctional conductance (gj) (106 +/- 3.1% increase). Enalapril (1 micrograms/ml) increased junctional conductance in isolated rat heart cell pairs by 106% within 4 minutes, an effect not suppressed by propranolol.
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