Key result
Men with type 2 diabetes had a significantly greater VLDL-TG storage rate in muscle tissue compared with nondiabetic men (P=0.02).
Why the study?
Does type 2 diabetes increase VLDL-TG fatty acid storage in skeletal muscle compared to nondiabetic controls?
Population
23 men (12 with type 2 diabetes, 11 nondiabetic) matched for age and body mass index.
Design
Cross-sectional
Authors
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May link T2D to muscle ectopic fat; leaves open causality and clinical relevance.
Observational (n=23)
Does type 2 diabetes increase VLDL-TG fatty acid storage in skeletal muscle compared to nondiabetic controls?
p-value: p=0.02
Men with type 2 diabetes exhibit increased VLDL-TG storage in skeletal muscle independent of LPL activity, potentially contributing to ectopic lipid deposition.
Andersen et al. (2016) conducted an observational in Type 2 diabetes (n=23). Type 2 diabetes vs. Nondiabetic men was evaluated on VLDL-TG storage rate in muscle tissue (p=0.02). Men with type 2 diabetes had a significantly greater VLDL-TG storage rate in muscle tissue compared with nondiabetic men (P=0.02).
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