March 1, 1983Diabetes
Very-Low-Density Lipoprotein Triglyceride Metabolism in Non-insulin-dependent Diabetes Mellitus: Relationship to Plasma Insulin and Free Fatty Acids
Key result
Type II diabetes linked to ~50% higher VLDL-TG, driven by decreased clearance capacity.
- n=25
Why the study?
The mechanism of elevated plasma triglycerides in non-insulin-dependent diabetes mellitus was unclear, particularly regarding VLDL-TG metabolism and its relation to insulin and free fatty acids.
Population
10 untreated male Pima Indian diabetics and 15 weight-matched male nondiabetic controls
Comparison
Pima Indian diabetics vs weight-matched nondiabetic controls
Design
Observational study using multicompartmental kinetic modeling
Authors
Discussion
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Member takes
Implication
May contribute to diabetic hypertriglyceridemia via reduced VLDL-TG clearance; leaves open generalizability and therapeutic implications beyond this cohort.
Study Design
Type
Observational (n=25)
Structured PICO
P
Population
25 male Pima Indians, comprising 10 untreated with type II diabetes and 15 weight-matched nondiabetic controls, evaluated for VLDL-TG metabolism.
C
Comparator
Weight-matched male nondiabetic controls
O
Outcome
Very-low-density lipoprotein triglyceride (VLDL-TG) metabolism (production rate and fractional catabolic rate)surrogate
Elevated VLDL-TG in Pima Indian men with type II diabetes is primarily due to decreased clearance capacity rather than increased production.
Cite This Study
Howard et al. (1983) conducted an observational in Non-insulin-dependent (type II) diabetes (n=25). Non-insulin-dependent (type II) diabetes vs. Weight-matched nondiabetic controls was evaluated on VLDL-TG concentrations and fractional catabolic rate. Type II diabetes in male Pima Indians was associated with VLDL-TG concentrations approximately 150% of nondiabetic controls, driven by decreased clearance capacity rather than increased production.