Key result
Intravenous immunoglobulin was associated with a higher left ventricular ejection fraction (62.2% vs 48.3%) at 4 weeks compared to conventional therapy in adults with acute fulminant myocarditis.
Why the study?
Does intravenous immunoglobulin improve left ventricular function and reduce arrhythmias in adult patients with acute fulminant myocarditis?
Population
58 adult patients with acute fulminant myocarditis, NYHA class II-IV, admitted to a single center in China.
Comparison
Intravenous immunoglobulin 400 mg/kg per day for… vs Conventional therapies without IVIG.
Design
Cohort
Follow-up
4 weeks
Authors
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IVIG may aid LVEF recovery in acute fulminant myocarditis but should not yet change practice; leaves open need for randomized confirmation.
Cohort (n=58)
No
Does intravenous immunoglobulin improve left ventricular function and reduce arrhythmias in adult patients with acute fulminant myocarditis?
Absolute Event Rate: 62.2% vs 48.3%
p-value: p=0.011
In adult patients with acute fulminant myocarditis, IVIG therapy may be associated with improved recovery of left ventricular function and reduced episodes of fulminant arrhythmias.
Yu et al. (2013) conducted a cohort in Acute fulminant myocarditis (n=58). Intravenous immunoglobulin vs. Non-IVIG therapy was evaluated on Left ventricular ejection fraction (LVEF) at 4 weeks (p=0.011). Intravenous immunoglobulin was associated with a higher left ventricular ejection fraction (62.2% vs 48.3%) at 4 weeks compared to conventional therapy in adults with acute fulminant myocarditis.
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