Key result
Enalapril maleate administration increased mean regional cerebral blood flow by 8% in patients with chronic cerebral infarction (0.05 < p < 0.1).
Why the study?
Does enalapril improve regional cerebral blood flow in patients with chronic cerebral infarction?
Does enalapril improve regional cerebral blood flow in patients with chronic cerebral infarction?
Effect estimate: 8% increase
p-value: p=0.05 < p < 0.1
Enalapril may have a beneficial effect on cerebral circulation in patients with chronic cerebral infarction, independent of its antihypertensive action.
May support enalapril-associated cerebral perfusion gains independent of BP change; leaves open need for randomized confirmation in chronic infarction.
UNLABELLED: The influence of long-term oral administration of enalapril maleate (an angiotensin II-converting enzyme inhibitor) on regional cerebral blood flow (rCBF) was studied in 10 patients with chronic cerebral infarction. The rCBF was measured by a 133Xe inhalation method before and after a mean of sixty-five days' administration of 5 mg of enalapril. RESULTS: Mean arterial blood pressure (MABP) was mildly decreased in 6 patients, but the average change in MABP was not significant (Endtidal partial pressure of carbon dioxide (PeC02) was not changed significantly. The mean rCBF was increased by 8% after administration of enalapril (0.05 less than p less than 0.1) There was no significant correlation between percent change in MABP and the percent change in rCBF. These results indicate that enalapril has not only antihypertensive action but also a beneficial effect on the cerebral circulation in patients with chronic cerebral infarction.
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Kobayashi et al. (1992) studied chronic cerebral infarction (n=10). Enalapril maleate vs. Baseline (before administration) was evaluated on regional cerebral blood flow (rCBF) (8% increase, p=0.05 < p < 0.1). Enalapril maleate administration increased mean regional cerebral blood flow by 8% in patients with chronic cerebral infarction (0.05 < p < 0.1).
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