March 4, 2013American Journal of HypertensionOpen Access

Predominance of AT1 Blockade Over Mas–Mediated Angiotensin-(1–7) Mechanisms in the Regulation of Blood Pressure and Renin–Angiotensin System in mRen2.Lewis Rats

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Why the study?

Does olmesartan medoxomil reduce blood pressure via Ang-(1-7) and the mas receptor in mRen2.Lewis hypertensive rats?

Population

mRen2.Lewis congenic hypertensive rats (n=28)

Comparison

Olmesartan medoxomil via osmotic minipumps for 6… vs Vehicle via osmotic minipumps

Design

Preclinical, randomized

Follow-up

6 weeks

Authors

JVJasmina VaragićUniversity of Utah SASarfaraz AhmadSwami Keshwanand Rajasthan Agricultural University JVJessica L. VonCannonWake Forest University

Discussion

Member takes

Implication

Olmesartan BP effects independent of Ang-(1-7)/mas in this rat model; leaves open pathway relevance to clinical hypertension.

Structured PICO

Does olmesartan medoxomil reduce blood pressure via Ang-(1-7) and the mas receptor in mRen2.Lewis hypertensive rats?

Population

mRen2.Lewis congenic hypertensive rats (n=28)

Intervention

Olmesartan medoxomil (0.5 mg/kg/day) via osmotic minipumps for 6 weeks, with randomization at 2 weeks to receive concomitant mas receptor antagonist A-779 (0.5 mg/kg/day) for the remaining 4 weeks

Comparator

Vehicle via osmotic minipumps

Outcome

Blood pressure and circulating and tissue components of the renin-angiotensin system (RAS)surrogate

The long-term antihypertensive effects of olmesartan are not mediated by Ang-(1-7) through the mas receptor in mRen2.Lewis rats.

Cite This Study

Varagić et al. (2013) studied this question.

synapsesocial.com/papers/6a228d57f56da133636d0522 https://doi.org/10.1093/ajh/hps090

Topics

Hypertension management

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Predominance of AT1 Blockade Over Mas–Mediated Angiotensin-(1–7) Mechanisms in the Regulation of Blood Pressure and Renin–Angiotensin System in mRen2.Lewis Rats

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Topics

Predominance of AT1 Blockade Over Mas–Mediated Angiotensin-(1–7) Mechanisms in the Regulation of Blood Pressure and Renin–Angiotensin System in mRen2.Lewis Rats

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Topics

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