Key result
Replacement of extracellular Na+ resulted in a 74.9% reduction in the slope conductance of the isoproterenol-induced Cl- current in isolated guinea pig ventricular myocytes.
Why the study?
Does intracellular Na+ modulate the cAMP-dependent regulation of ion channels in isolated guinea pig ventricular myocytes?
Population
Isolated single guinea pig ventricular myocytes
Comparison
Replacement of extracellular Na+ with… vs Control conditions
Design
Preclinical
Authors
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Intracellular Na+ may modulate cAMP-dependent currents in animal myocytes; leaves open relevance to human arrhythmias or HF.
Does intracellular Na+ modulate the cAMP-dependent regulation of ion channels in isolated guinea pig ventricular myocytes?
Effect estimate: 74.9% reduction
Intracellular Na+ concentration plays an important role in modulating the response of cardiac ion channels to cAMP-dependent autonomic regulation.
Harvey et al. (1991) studied Isolated guinea pig ventricular myocytes. Replacement of extracellular Na+ vs. Presence of extracellular Na+ (140 mM) was evaluated on Magnitude of the beta-adrenergically regulated Cl- current (ICl) (74.9% reduction). Replacement of extracellular Na+ resulted in a 74.9% reduction in the slope conductance of the isoproterenol-induced Cl- current in isolated guinea pig ventricular myocytes.
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