Biventricular Remodeling in Murine Models of Right Ventricular Pressure Overload
Population
Adult, male mice
Comparison
Constriction of the pulmonary artery or thoracic… vs Controls
Design
Preclinical
Authors
Discussion
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Implication
Distinguishes primary from secondary RVPO effects on LV in mice; leaves open whether patterns inform human biventricular failure.
Structured PICO
P
Population
Adult, male mice
I
Intervention
Constriction of the pulmonary artery (model of primary right ventricular pressure overload) or thoracic aorta (model of secondary right ventricular pressure overload)
C
Comparator
Controls
O
Outcome
Changes in biventricular hemodynamics (stroke work, dP/dtmax, Ees, ventriculo-arterial coupling), myocyte hypertrophy, fibrosis, and expression of calcineurin and TGFβ1surrogate
Primary and secondary right ventricular pressure overload induce distinct patterns of biventricular structural, functional, and molecular remodeling in murine models.
Cite This Study
Kapur et al. (2013) studied this question.