Key result
Systemic hypertension was associated with significantly impaired left ventricular global longitudinal strain compared to normotensive controls (SMD 1.07; 95% CI 0.77-1.36; P<0.0001).
Why the study?
Available evidence on systolic dysfunction in systemic hypertension, as assessed by left ventricular mechanics, was limited to single studies.
Does two-dimensional speckle tracking echocardiography detect impaired global longitudinal strain in uncomplicated hypertensive patients compared to normotensive controls?
Population
4276 individuals (2187 mostly uncomplicated hypertensive patients and 2089 normotensive controls)
Comparison
Hypertensive patients vs normotensive controls
Design
Systematic meta-analysis of two-dimensional speckle-tracking studies
Authors
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GLS may identify subclinical systolic dysfunction in hypertension missed by EF; confirms this pattern in a large pooled meta-analysis.
Meta-Analysis (n=4,276)
Does two-dimensional speckle tracking echocardiography detect impaired global longitudinal strain in uncomplicated hypertensive patients compared to normotensive controls?
Standardized Mean Difference: 1.07 (95% CI 0.77–1.36)
p-value: p=< 0.0001
GLS assessment by speckle tracking echocardiography unmasks subclinical systolic dysfunction in uncomplicated hypertension that is undetected by conventional ejection fraction.
Tadić et al. (2021) conducted a meta-analysis in Systemic hypertension (n=4,276). Systemic hypertension vs. Normotensive controls was evaluated on Left ventricular global longitudinal strain (GLS) (SMD 1.07, 95% CI 0.77-1.36, p=< 0.0001). Systemic hypertension was associated with significantly impaired left ventricular global longitudinal strain compared to normotensive controls (SMD 1.07; 95% CI 0.77-1.36; P<0.0001).
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