Key result
Uncontrolled type 2 diabetes mellitus was associated with significantly higher Mean Platelet Volume and Platelet Distribution Width compared to controlled diabetes.
Why the study?
Platelet activation contributes to the prothrombotic state in diabetes, and MPV and PDW may help detect this prothrombotic state early in patients with varying glycemic control.
Do platelet indices (MPV, PDW, platelet count) differ between controlled and uncontrolled Type 2 Diabetes Mellitus patients?
Cross-Sectional (n=277)
Do platelet indices (MPV, PDW, platelet count) differ between controlled and uncontrolled Type 2 Diabetes Mellitus patients?
Higher MPV and PDW in uncontrolled Type 2 diabetes suggest increased platelet activation and a prothrombotic state, potentially serving as inexpensive markers for early detection of thrombotic complications.
Answers are grounded in this paper and cite their sources.
Higher MPV/PDW in uncontrolled T2DM may signal prothrombotic risk; leaves open predictive utility pending prospective studies.
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Samaddar et al. (2022) conducted a cross-sectional in Type 2 Diabetes Mellitus (n=277). Uncontrolled Type 2 Diabetes Mellitus (HbA1c > 7%) vs. Controlled Type 2 Diabetes Mellitus (HbA1c ≤ 7%) was evaluated on Mean Platelet Volume (MPV), Platelet Distribution Width (PDW), and platelet count. Uncontrolled type 2 diabetes mellitus was associated with significantly higher Mean Platelet Volume and Platelet Distribution Width compared to controlled diabetes.
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