Key result
Type-2 diabetes linked to increased mean platelet volume, tracking with HbA1c and disease duration.
Why the study?
Platelets may contribute to vascular complications in diabetes, and mean platelet volume (MPV) can serve as a marker for platelet activity in Type-2 diabetes mellitus.
Does Type-2 diabetes mellitus increase mean platelet volume and alter other platelet parameters compared to non-diabetics?
Population
100 Type-2 diabetic patients aged 30-60 years and 100 age-matched non-diabetic controls
Comparison
Type-2 diabetic patients vs non-diabetic subjects
Design
Cross-sectional study
Authors
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May support MPV monitoring in T2DM; leaves open prospective validation for vascular risk prediction.
Cross-Sectional (n=200)
No
Does Type-2 diabetes mellitus increase mean platelet volume and alter other platelet parameters compared to non-diabetics?
Mean platelet volume is significantly elevated in patients with Type-2 diabetes, particularly those with poor glycemic control or longer disease duration, suggesting its potential as a marker for vascular complications.
Swaminathan et al. (2016) conducted a cross-sectional in Type-2 diabetes mellitus (n=200). Type-2 diabetes mellitus vs. Non-diabetic subjects was evaluated on Mean platelet volume (MPV) and other platelet parameters. Type-2 diabetes was associated with significantly increased mean platelet volume compared to non-diabetic controls (N=200), with further increases seen in patients with HbA1c >7% or >10 years disease duration.
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