Key result
T2DM is linked to ~1 fL higher mean platelet volume versus non-diabetic controls.
Why the study?
Increased mean platelet volume is emerging as a risk factor for vascular complications in type 2 diabetes mellitus due to thrombogenicity.
Is mean platelet volume increased in patients with type 2 diabetes mellitus compared to non-diabetic controls?
Observational (n=150)
No
Is mean platelet volume increased in patients with type 2 diabetes mellitus compared to non-diabetic controls?
Mean platelet volume is significantly elevated in patients with type 2 diabetes, suggesting it could serve as a simple, economical marker for monitoring thrombogenic risk.
May signal heightened thrombotic risk in type 2 diabetes; hypothesis-generating and should not yet change practice.
Background: Most Diabetes Mellitus related deaths are due to increased risk of micro- and macrovascular complications of the disease. Larger platelets with higher mean platelet volume increase the propensity to thrombosis. Therefore, increased MPV is emerging as a risk factor for vascular complications.Methods: This prospective study was conducted on 100 subjects with type II DM and 50 non-diabetic controls over a period of 3 months. To determine mean platelet volume (MPV) and platelet count (PC) in diabetics (type2) and non-diabetics and to determine correlation of MPV and platelet count with fasting blood sugar.Results: Significant increase in value of MPV was seen in diabetics.Conclusion: MPV being a simple, economical test, can serve as an effective tool in monitoring the patients for thrombogenicity especially in patients with altered blood glucose metabolism. DOI: 10.21276/APALM.1381
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Umarani et al. (2017) conducted an observational in Type 2 Diabetes Mellitus (n=150). Type 2 Diabetes Mellitus vs. Non-diabetic controls was evaluated on Mean Platelet Volume (fL) (p=<0.001). Patients with type 2 diabetes mellitus had a significantly higher mean platelet volume compared to non-diabetic controls (9.64 fL vs 8.66 fL, p<0.001).
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