Key result
Right ventricular septal pacing preserved long-term left ventricular function and resulted in significantly smaller left ventricular dyssynchrony compared to right ventricular apical pacing (Tsys dispersion 75 ms vs 110 ms, P<0.001).
Why the study?
Does right ventricular septal pacing preserve long-term left ventricular function and minimize dyssynchrony compared to right ventricular apical pacing in patients with normal baseline QRS duration?
Cohort (n=55)
No
Does right ventricular septal pacing preserve long-term left ventricular function and minimize dyssynchrony compared to right ventricular apical pacing in patients with normal baseline QRS duration?
Absolute Event Rate: 75% vs 110%
p-value: p=<0.001
Right ventricular septal pacing guided by paced QRS morphology preserves long-term left ventricular function by minimizing pacing-induced left ventricular dyssynchrony compared to apical pacing.
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RVS may preserve LV function better than RVA; leaves open whether RCTs should change pacing site selection.
Takemoto et al. (2009) conducted a cohort in Advanced atrioventricular block or sinus node dysfunction (n=55). Right ventricular septal (RVS) pacing vs. Right ventricular apical (RVA) pacing was evaluated on Tsys dispersion (difference between longest and shortest time-to-peak systolic velocity in 12 LV segments) (p=<0.001). Right ventricular septal pacing preserved long-term left ventricular function and resulted in significantly smaller left ventricular dyssynchrony compared to right ventricular apical pacing (Tsys dispersion 75 ms vs 110 ms, P<0.001).
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