Key result
Continuous infusion of angiotensin II in rats induced a fivefold to eightfold increase in left ventricular fibronectin mRNA and acute cardiac fibrosis, which was attenuated by losartan or ACE inhibitors.
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Mechanistic support for RAAS blockade in fibrosis; leaves open human cardiac remodeling implications.
Crawford et al. (1994) studied Cardiac fibrosis. Angiotensin II vs. Normal hearts / withdrawal / losartan / ACE inhibitors was evaluated on Fibronectin steady-state mRNA and cardiac fibrosis. Continuous infusion of angiotensin II in rats induced a fivefold to eightfold increase in left ventricular fibronectin mRNA and acute cardiac fibrosis, which was attenuated by losartan or ACE inhibitors.
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