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June 13, 2026Pulmonary MedicineOpen Access

ACE2 Expression and Clinical Biomarkers in COVID‐19: Associations With Disease Severity

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Authors

KSKazhin Rahim Ali SaeedPJPaywast Jamal Jalal

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Overview

Prospective pilot study assesses ACE2 and inflammation in Kurdish COVID-19 cases, indicating complex severity factors.

Key Points

  • This research aims to investigate the role of ACE2 expression and clinical biomarkers in relation to COVID-19 severity, particularly within the Kurdish population.
  • Conducted a prospective pilot study with 45 participants categorized into mild, severe, and control groups.
  • Analyzed ACE2 mRNA expression using quantitative real-time PCR (qRT-PCR) and assessed biochemical parameters.
  • Performed statistical analyses including one-way ANOVA and nonparametric tests for group comparisons.
  • ACE2 expression significantly increased in severe COVID-19 cases compared to controls (mean difference = 0.568; adjusted p = 0.032).
  • Identified elevated levels of CRP, ESR, and ferritin alongside reduced lymphocyte counts as markers for severe disease.
  • Machine learning analysis revealed CRP, ESR, and GPT as significant predictors of COVID-19 severity.

Cite This Study

Saeed et al. (2026) studied this question.

synapsesocial.com/papers/6a2cf6d7faef96ed7f0586d8https://doi.org/10.1155/pm/1013605
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