Key result
Visit-to-visit variability of blood pressure is associated with increased risk for cardiovascular outcomes, though further research is needed on underlying mechanisms and interventions to lower it.
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Visit-to-visit variability of blood pressure is an important clinical metric associated with cardiovascular risk, highlighting the need for further research on its mechanisms and potential interventions.
Blood pressure (BP) is known to vary over time within individuals. Although variability between office visits has traditionally been regarded as a barrier to the accurate measurement of BP, several recent studies have reported strong associations between visit-to-visit variability (VVV) of BP and increased risk for cardiovascular outcomes. In this article, we review data on VVV of BP and outcomes, determinants of high VVV of BP including demographics, medical history, and antihypertensive medication classes and poor adherence. In addition, we will discuss methodological issues related to interpreting data from studies of VVV of BP and data on BP variability assessed outside of the office setting. In conclusion, we highlight pressing research needs related to VVV of BP including those aimed at determining the mechanism underlying high VVV of BP, assessing interventions that lower VVV of BP and the utility of quantifying VVV of BP using measurements obtained in routine clinical practice.
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Muntner et al. (2013) conducted a review in Visit-to-visit variability of blood pressure. Visit-to-visit variability of blood pressure was evaluated. Visit-to-visit variability of blood pressure is associated with increased risk for cardiovascular outcomes, though further research is needed on underlying mechanisms and interventions to lower it.
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