Why the study?
NDUFA7 is a novel HCM-associated gene, but its biological role in the heart and the molecular mechanisms underlying cardiac hypertrophy remain unknown.
Does ndufa7 depletion cause cardiac hypertrophy and functional defects in preclinical models?
Does ndufa7 depletion cause cardiac hypertrophy and functional defects in preclinical models?
NDUFA7 depletion promotes ROS production and calcineurin signaling activation, contributing to pathological cardiac hypertrophy in preclinical models.
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NDUFA7 findings in hypertrophy remain preliminary; leaves open its mechanistic or therapeutic relevance in cardiomyopathy.
Shi et al. (2020) studied this question.
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