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June 17, 2026Urogynecology

Perioperative Gabapentin and Opioid Requirements: A Randomized Controlled Trial

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Authors

AGAnna GuanzonDHDouglass HaleDMDavid Morse

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Overview

Randomized trial evaluates gabapentin's effectiveness in reducing opioid prescriptions post-surgery, indicating no significant difference found.

Key Points

  • To assess if preoperative gabapentin is noninferior to a regimen of preoperative and postoperative gabapentin in reducing opioid prescriptions after prolapse surgery.
  • Randomized double-blind placebo-controlled trial
  • Included 114 patients, divided into control (gabapentin) and experimental (placebo) groups
  • Measured opioid prescription rates at discharge and other pain-related outcomes.
  • Control group required opioid prescriptions at discharge at a rate of 27.0% compared to 32.0% in the experimental group (P=0.57)
  • No significant difference in opioid refill requests within 6 weeks postoperatively (10.9% vs 15.3%, P=0.49)
  • Noninferiority was not established as the upper margin of the 95% CI exceeded the 20% threshold.

Cite This Study

Guanzon et al. (2026) studied this question.

synapsesocial.com/papers/6a323ed9d50b63ecad207da4https://doi.org/10.1097/spv.0000000000001891
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Preoperative Gabapentin for Vaginal Prolapse Procedures: A Randomized Trial2025
  2. 2Exploring the effects of preoperative gabapentin on postoperative pain and opioid consumption in patients undergoing orthopedic surgery under spinal anesthesia2025
  3. 3Effect of Gabapentin on Pain after Cardiac Surgery: A Randomised, Double-Blind, Placebo-Controlled Trial2010 · 52 citations
  4. 4Postoperative Gabapentinoid use Reduces Long-Term Opioid Reliance After Long-Segment Lumbar Instrumentation2025 · 1 citations
  5. 5Perioperative Gabapentin After Benign Anorectal Surgery: Statistically Significant but Clinically Uncertain? A Systematic Review and Meta-Analysis2026