Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
July 26, 2026The American Surgeon

Perioperative Gabapentin After Benign Anorectal Surgery: Statistically Significant but Clinically Uncertain? A Systematic Review and Meta-Analysis

View Full Paper
Ask AI
Bookmark
Share

Authors

BPBernardo Fontel PompeuFAFábio Henrique Nogueira Nóbrega AlvesBMBianca Vaz Micherino

Discussion

Loading...

Member takes

Overview

Systematic review demonstrates gabapentin reduces pain post-anorectal surgery, indicating uncertain clinical relevance.

Key Points

  • This review aims to evaluate the effectiveness of perioperative gabapentin in reducing postoperative pain after benign anorectal surgery.
  • Systematic search of PubMed, Scopus, and Cochrane Central Register for studies through May 2025.
  • Included randomized clinical trials and observational cohorts comparing preoperative gabapentin with placebo or standard analgesia in anorectal surgery.
  • Analyses used random-effects model for mean differences and Bayesian random-effects meta-analysis.
  • Gabapentin led to significantly lower 24-hour VAS scores (MD = −2.10 cm; 95% CI −3.98 to −0.22; P = 0.029).
  • The Bayesian model showed a posterior probability of benefit of 99.8%.
  • Despite statistical significance, clinical relevance remains uncertain due to high heterogeneity.

Cite This Study

Pompeu et al. (2026) studied this question.

synapsesocial.com/papers/6a65a8c9d3aea3239cd78fcdhttps://doi.org/10.1177/00031348261471467
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1A single preoperative dose of Gabapentin decreases postoperative pain in ambulatory anal surgeries2023 · 1 citations
  2. 2Exploring the Safety and Efficacy of Gabapentin Use In Perioperative Analgesia Protocols: An Integrative Review.2026
  3. 3Efficacy of Oral Gabapentin and Acetaminophen for Postoperative Analgesia in Anorectal Surgery: A Fuzzy Logic Evaluation2024
  4. 4Exploring the effects of preoperative gabapentin on postoperative pain and opioid consumption in patients undergoing orthopedic surgery under spinal anesthesia2025
  5. 5Perioperative Gabapentin and Opioid Requirements: A Randomized Controlled Trial2026