Key result
The presence of the T allele of the IL6R variant rs4845625 was significantly associated with an increased risk of early recurrence of atrial fibrillation after catheter ablation (OR 1.84).
Why the study?
Does the rs4845625 variant of the IL6R gene increase the risk of atrial fibrillation recurrence after catheter ablation in a Chinese Han population?
Cohort (n=278)
No
Does the rs4845625 variant of the IL6R gene increase the risk of atrial fibrillation recurrence after catheter ablation in a Chinese Han population?
Odds Ratio: 1.84 (95% CI 1.31–2.59)
p-value: p=4.10 x 10^-4
The rs4845625 variant of the IL6R gene is significantly associated with an increased risk of both early and late recurrence of atrial fibrillation following catheter ablation in a Chinese Han population.
Does not support routine IL6R genotyping for ablation decisions; leaves open prospective validation in broader populations.
BACKGROUND: Recent studies have identified a variant, rs4845625, in the interleukin-6 receptor (IL6R) gene associated with Atrial Fibrillation (AF). Levels of circulating interleukin-6 and other proinflammatory molecules have consistently been associated with a risk for AF and its recurrence after catheter ablation. This study tested the hypothesis that variant rs4845625 is associated with AF recurrence after catheter ablation in a Chinese Han population. METHODS: A total of 278 consecutive patients (mean age 59.4±11.5 years, 43% female) with paroxysmal (36.0%), persistent (59.7%), and permanent (4.3%) AF who underwent catheterablation from 2007-2011, were included in this study. Patients were monitored for 12 months for a recurrence of AF. The SNP rs4845625 was genotyped using high resolution melting analysis. RESULTS: In our study cohort, an early recurrence of AF (ERAF), defined as a recurrence within the first 4 weeks, was observed in 42.8% of the patients, whereas late recurrence of AF (LRAF) (between 3 and 12 months) occurred in 25.9% of the patients. No significant differences in baseline clinical or echocardiographic characteristics were observed between patients with ERAF and LRAF. In contrast, the presence of the T allele of rs4845625 was associated with an increase in the risk for both ERAF (odds ratio [OR]: 1.84, 95% confidence interval [CI]: 1.31-2.59, p = 4.10×10-4) and LRAF (OR: 1.92, 95% CI: 1.30-2.81, p = 0.001). Furthermore, this association was significant after adjustments for age, sex, hypertension, diabetes and other risk factors. No significant relationship between rs4845625 and serum levels of IL6 was observed. CONCLUSIONS: In this study, a variant of the IL6R gene, rs4845625, was found confer risk to AF recurrence after catheter ablation in a Chinese Han population. Our findings indicated that the IL6R pathway or inflammation may play important rols in the recurrence of AF after catheter ablation.
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Wu et al. (2014) conducted a cohort in Atrial Fibrillation (n=278). IL6R variant rs4845625 (T allele) vs. Absence of T allele (C allele) was evaluated on Early recurrence of atrial fibrillation (ERAF) within the first 4 weeks (OR 1.84, 95% CI 1.31-2.59, p=4.10 x 10^-4). The presence of the T allele of the IL6R variant rs4845625 was significantly associated with an increased risk of early recurrence of atrial fibrillation after catheter ablation (OR 1.84).
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