Key result
The IL-6 -634 GG genotype was associated with a 4.7-fold increased risk of atrial fibrillation compared to CC and CG genotypes in elderly Han Chinese patients with essential hypertension (OR 4.7353).
Why the study?
Is the IL-6 -634C/G polymorphism associated with an increased risk of atrial fibrillation in elderly Han Chinese patients with essential hypertension?
Case-Control (n=169)
No
Is the IL-6 -634C/G polymorphism associated with an increased risk of atrial fibrillation in elderly Han Chinese patients with essential hypertension?
Odds Ratio: 4.7353 (95% CI 0.9537–23.5116)
Absolute Event Rate: 9.33% vs 2.13%
p-value: p=0.0382
The IL-6 -634C/G polymorphism, specifically the GG genotype and G allele, is significantly associated with an increased risk of atrial fibrillation in elderly Han Chinese patients with essential hypertension.
May support genetic risk stratification in elderly hypertensives; leaves open clinical utility and causal role pending prospective validation.
There is an accumulating body of evidence indicating a strong association between inflammation and the pathogenesis of atrial fibrillation (AF). Interleukin-6 (IL-6) is a pleiotropic cytokine, functions as a mediator of inflammatory response, and has both proinflammatory and anti-inflammatory properties. The aim of the present study was to investigate the association of the -634C/G polymorphism of the IL-6 gene with AF in elderly Han Chinese patients with essential hypertension (EH). A total of 169 elderly patients with EH were eligible for this study. Patients with AF (n=75) were allocated to the AF group, and 94 subjects without AF to the control group. The polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) technique was used to assess the genotype frequencies. The distribution of the IL-6 -634C/G genotypes (CC, CG, and GG) was 67.02%, 30.85%, and 2.13% in the controls, and 50.67%, 40.00%, and 9.33% in AF subjects, respectively (P=0.0312). The frequency of the G allele in the AF group was significantly higher than that in the control group (29.33% vs. 17.55%, P=0.0103). Compared with the CC and CG genotypes, the GG homozygote had a 4.7353-fold increased risk of AF [95% confidence interval (CI)=0.9537-23.5116, P=0.0382]. These findings suggest that the IL-6 -634C/G polymorphism is associated with AF, and the G allele has increased risk of AF in elderly Han Chinese patients with EH.
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Li et al. (2012) conducted a case-control in Atrial Fibrillation in Essential Hypertension (n=169). IL-6 -634 GG genotype vs. IL-6 -634 CC and CG genotypes was evaluated on Risk of atrial fibrillation (OR 4.7353, 95% CI 0.9537-23.5116, p=0.0382). The IL-6 -634 GG genotype was associated with a 4.7-fold increased risk of atrial fibrillation compared to CC and CG genotypes in elderly Han Chinese patients with essential hypertension (OR 4.7353).
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