Key result
Carrying the G allele of the IL-6 -634C/G polymorphism was associated with a 2.79-fold increased risk of left atrial thrombus or severe spontaneous echocontrast in patients with atrial fibrillation.
Why the study?
Is the IL-6 -634C/G polymorphism associated with left atrial thrombus and severe spontaneous echocontrast in Han Chinese patients with atrial fibrillation?
Case-Control (n=76)
Is the IL-6 -634C/G polymorphism associated with left atrial thrombus and severe spontaneous echocontrast in Han Chinese patients with atrial fibrillation?
Odds Ratio: 2.79
p-value: p=0.0391
The IL-6 -634C/G polymorphism, specifically the G allele, is associated with a significantly increased risk of left atrial thrombus and severe spontaneous echocontrast in Han Chinese patients with atrial fibrillation.
Should not yet guide AF thrombus risk assessment; leaves open prospective validation of IL-6 genotyping.
Atrial fibrillation (AF) not only is an independent risk factor for death but also confers significant risk of morbidity from stroke associated with left atrial thrombus. The association of interleukin 6 (IL-6) polymorphism with thrombus in AF has not been investigated before. We carried out a case-control study in Han Chinese. The IL-6 -634C/G genotypes of 31 patients with thrombus and 45 patients without thrombus were detected by polymerase chain reaction and restriction fragment length polymorphism. The frequencies of the IL-6 genotypes (CC, CG, and GG) were 29.03%, 54.54%, and 16.13% for the patients with thrombus, and 55.56%, 40.00%, and 4.44% for the patients without thrombus, respectively (P = .0391). Compared with the CC genotype, the G allele carriers (CG + GG) had a 2.79-fold increased risk of thrombus or severe spontaneous echocontrast (SEC). These results suggest that IL-6 -634C/G polymorphism is associated with thrombus and severe SEC, and the G allele is an independent risk for thrombus and severe SEC in Han Chinese patients with AF.
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Deng et al. (2012) conducted a case-control in Atrial fibrillation (n=76). IL-6 -634C/G polymorphism (G allele carriers) vs. CC genotype was evaluated on Left atrial thrombus or severe spontaneous echocontrast (SEC) (OR 2.79, p=0.0391). Carrying the G allele of the IL-6 -634C/G polymorphism was associated with a 2.79-fold increased risk of left atrial thrombus or severe spontaneous echocontrast in patients with atrial fibrillation.
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