Key result
The G allele of the IL-27 genetic variant rs153109 was associated with increased susceptibility to atrial fibrillation in the Chinese Han population (OR 1.35; 95% CI 1.06-1.71; p=0.02).
Why the study?
Are IL-27 gene polymorphisms associated with atrial fibrillation susceptibility in the Chinese Han population?
Case-Control (n=573)
Are IL-27 gene polymorphisms associated with atrial fibrillation susceptibility in the Chinese Han population?
The IL-27 genetic polymorphism rs153109 may be associated with increased susceptibility to atrial fibrillation in the Chinese Han population.
Answers are grounded in this paper and cite their sources.
No immediate clinical implications for AF risk stratification; hypothesis-generating for IL-27 variants in arrhythmia predisposition.
AIM: Atrial fibrillation (AF) is the most common cardiac arrhythmia. No data are available on the association between the polymorphisms of interleukin-27 (IL-27) and AF in the Chinese Han population. This study was performed to determine if polymorphisms within the IL-27 gene are involved in the AF susceptibility. METHODS: Two hundred seventy AF patients and 303 healthy individuals were examined for two IL-27 gene polymorphisms (rs153109 and rs17855750) by polymerase chain reaction-restriction fragment length polymorphism methodology. RESULTS: An association between the IL-27 single nucleotide polymorphism (SNP) rs153109 and AF was found in Chinese Han population. The G allele and GG genotype of rs153109 were associated with increased AF risk (odds ratio [OR]: 1.35, 95% confidence intervals [CI] = 1.06-1.71, p = 0.02 and OR: 1.66, 95% CI = 1.03-2.65, p = 0.03 in the recessive genetic model, respectively). The significance of the association between the GG genotype and AF risk did not survive a Bonferroni's correction. Similarly, no significant differences in the allele and genotype frequencies of the rs17855750 SNP was observed between the AF patients and controls. CONCLUSIONS: Our findings indicated that the IL-27 genetic polymorphisms may be associated with susceptibility of AF in Chinese Han population.
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Chen et al. (2017) conducted a case-control in Atrial fibrillation (n=573). IL-27 gene polymorphism rs153109 G allele vs. Healthy controls was evaluated on Atrial fibrillation susceptibility (OR 1.35, 95% CI 1.06-1.71, p=0.02). The G allele of the IL-27 genetic variant rs153109 was associated with increased susceptibility to atrial fibrillation in the Chinese Han population (OR 1.35; 95% CI 1.06-1.71; p=0.02).
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