Key result
Among 165 clinical samples from goslings with fatal gout, the positive infection rate of novel gosling astrovirus was 100%, with genomic analysis revealing high mutation rates in ORF1a and ORF2.
Why the study?
Severe outbreaks of fatal gout caused by novel gosling astroviruses emerged in several Chinese provinces with significant economic impact, prompting assessment of the infection status of GoAstVs causing gout.
Population
165 clinical samples from goslings from seven farms across different Chinese provinces
Design
Observational viral screening and genomic sequencing study
Authors
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Novel GoAstVs sequenced from gout outbreaks in goslings; leaves open etiology, transmission, and control strategies for poultry.
Observational (n=165)
Yes
Novel gosling astroviruses are highly prevalent in fatal gout outbreaks in Chinese goslings and exhibit significant genomic mutations that may relate to pathogenicity.
Chen et al. (2019) conducted an observational in Fatal gout (n=165). Gosling astrovirus (GoAstV) infection was evaluated on Viral infection rates. Among 165 clinical samples from goslings with fatal gout, the positive infection rate of novel gosling astrovirus was 100%, with genomic analysis revealing high mutation rates in ORF1a and ORF2.
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