Key result
Inoculation of one-day-old goslings with novel goose-origin astrovirus caused typical gout and resulted in 30% and 38% mortality via oral and subcutaneous routes respectively, compared to 0% in controls.
Why the study?
A novel goose-origin astrovirus has caused gout in goslings across China, but understanding of its dynamic distribution, tissue tropism, and pathogenesis is incomplete.
This study characterizes the tissue tropism and pathogenicity of a novel goose-origin astrovirus in goslings, highlighting significant damage to the kidney, liver, heart, and spleen.
Answers are grounded in this paper and cite their sources.
May indicate cardiac tropism in goslings; hypothesis-generating for pathogenesis and leaves open cross-species relevance.
BACKGROUND: A novel goose-origin astrovirus (GoAstV) has broken out across China in recent years, causing gout in goslings with a mortality rate of around 50%. However, our understanding of the dynamic distribution, tissue tropism and pathogenesis of GoAstV is incomplete. In order to assess its pathogenicity, one-day-old goslings were inoculated separately with GoAstV via oral and subcutaneous injection routes. RESULTS: Clinical symptoms, gross and microscopic lesions, blood biochemical parameters and viral loads were detected and recorded for 20 days after infection. Typical gout was observed in experimental goslings. GoAstV can be replicated in tissues and cause pathological damage, especially in the kidney, liver, heart and spleen. Virus-specific genomic RNA was detected in blood, cloacal swabs and all representative tissues, and virus shedding was detected up to 20 days after inoculation, suggesting that GoAstV has a wide tissue tropism and spread systematically after inoculation. The viral copy numbers examined in kidney were the highest, followed by spleen and liver. CONCLUSION: This experiment determined the accurate value of viral loads and biochemical indicators of GoAstV-induced goslings. These findings increase our understanding of the pathogenicity of GoAstV in goslings and provide more reference for future research.
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Yin et al. (2021) studied Goose-origin astrovirus (GoAstV) infection and gout (n=150). Goose-origin astrovirus (GoAstV) SDPY strain vs. Phosphate buffer saline (PBS) was evaluated on Mortality (subcutaneous infection group) (p=<0.01). Inoculation of one-day-old goslings with novel goose-origin astrovirus caused typical gout and resulted in 30% and 38% mortality via oral and subcutaneous routes respectively, compared to 0% in controls.
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