Key result
A novel divergent goose astrovirus (AStV-SDPY) with a 7,252 nt genome and 48.8%-68.2% nucleotide homology to classic strains was identified as the causative agent of gosling gout in China.
The causative agent of a severe gout outbreak in goslings in China was identified as a novel divergent goose astrovirus.
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Novel astrovirus identified as gosling gout cause; leaves open surveillance, control, and zoonotic questions.
A severe infectious disease characterized with gout, haemorrhage and swellings of kidneys has affected goslings around the major goose-producing regions in China since November 2016. A Novel goose-origin astrovirus (AStV), designated as AStV/SDPY/Goose/1116/17 (AStV-SDPY) strain, was isolated from diseased goslings, and experimental reproduction of gout was successful using the AStV-SDPY strain. Additionally, the AStV-SDPY was conducted for its full genome sequencing characterization using next-generation sequencing (NGS) technique on Illumina HiSeq platform. A complete genome of the AStV-SDPY was 7,252 nt in length and encoded three viral proteins. Phylogenetic analysis revealed that AStV-SDPY strain belongs to an independent branch of avian astroviruses, and the nucleotide homology among AStV-SDPY and other classic avian astrovirus strains was only 48.8%-68.2%. Results of above data indicated the causative agent of the gosling gout occurring in China is a novel divergent goose astrovirus.
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Yang et al. (2018) studied Gosling gout. Novel goose-origin astrovirus (AStV-SDPY) was evaluated on Genomic characterization and experimental reproduction of gout. A novel divergent goose astrovirus (AStV-SDPY) with a 7,252 nt genome and 48.8%-68.2% nucleotide homology to classic strains was identified as the causative agent of gosling gout in China.
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