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June 28, 2026Photobiomodulation Photomedicine and Laser Surgery

Photobiomodulation of Human Embryonic Stem Cell-Derived Mesenchymal Stem Cells by 355 nm Low-Level Ultraviolet Laser Exposure

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Authors

KAKhalid M. AlGhamdiAKAshok KumarAMAmer Mahmood

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Overview

Randomized trial shows UVA photobiomodulation enhances cell proliferation and osteogenesis in stem cells, indicating new therapeutic options.

Key Points

  • This investigation aims to evaluate the effects of ultraviolet A photobiomodulation on human embryonic stem cell-derived mesenchymal stem cells.
  • hESC-MSCs cultured and exposed to UVA PBM at energy densities from 0.5 to 5.0 J/cm²
  • Key parameters of proliferation, viability, migration, and osteogenic differentiation were assessed
  • PCR was performed to analyze expression of osteogenic markers after treatment
  • UVA PBM significantly increased proliferation at energy densities of 0.5 to 2.0 J/cm²
  • Cell viability improved at energy densities of 0.5 to 3.0 J/cm²
  • Mineralization and osteogenic marker expression increased significantly at low energy densities

Cite This Study

AlGhamdi et al. (2026) studied this question.

synapsesocial.com/papers/6a40ba2161bb0a67205c6235https://doi.org/10.1177/25785478261460627
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Also Consider

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  5. 5In vitro Comparison of Light-Emitting Diodes and Carnosic Acid Effects on Keratinocyte Proliferation and Wound Healing2012 · 4 citations