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June 29, 2026Fundamental and Clinical Pharmacology

Synergistic Cardioprotection of Colchicine and Hyperbaric Oxygen Therapy in a Rat Model of Remote Ischemia‐Reperfusion Injury

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Authors

ŞKŞahhan KılıçSASüha AsalMBMert Babaoğlu

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Overview

Randomized trial reveals improved myocardial protection in rats through colchicine and oxygen therapy, suggesting a new treatment approach.

Key Points

  • This study aims to investigate the cardioprotective effects of colchicine and hyperbaric oxygen therapy against myocardial remote ischemia-reperfusion injury.
  • Male Sprague-Dawley rats (n = 6 per group) were assigned to Sham, I/R, I/R + colchicine, I/R + HBOT, and I/R + HBOT + colchicine groups.
  • Ischemia-reperfusion was induced by aortic clamping for 60 minutes, followed by 120 hours of reperfusion.
  • Cardiac damage, oxidative stress, inflammation, and NRF-2/HO-1 signaling were measured, alongside electrocardiography (ECG) assessment.
  • I/R resulted in severe myocardial injury with Hs-Troponin T of 568.54 pg/mL and TNF-α of 582.89 pg/mL.
  • Combination treatment of HBOT + colchicine significantly reduced Hs-Troponin T to 342.07 pg/mL and TNF-α to 278.82 pg/mL, surpassing monotherapy effects.
  • NRF-2/HO-1 activation was enhanced, demonstrating restored redox balance with a notable %DIS/NT of 26.31.

Cite This Study

Kılıç et al. (2026) studied this question.

synapsesocial.com/papers/6a420ba8f91bb43ea9192a0chttps://doi.org/10.1111/fcp.70102
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