Key result
HCV IRES domains function as RNA-based initiation factors to form 48S initiation complexes and 80S ribosomes with only a subset of canonical eukaryotic initiation factors.
This review summarizes the structural features and functions of HCV IRES domains in mediating cap-independent translation initiation.
IRES motifs enable selective viral translation; leaves open targeted RNA-based antivirals pending further validation.
The HCV IRES is a highly structured RNA which mediates cap-independent translation initiation in higher eukaryotes. This function is encoded in conserved structural motifs in the two major domains of HCV and HCV-like IRESs, which play crucial and distinct roles along the initiation pathway. In this review, I discuss structural features of IRES domains and how these RNA motifs function as RNA-based initiation factors to form 48S initiation complexes and 80S ribosomes with only a subset of canonical, protein-based eukaryotic initiation factors.
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Peter J. Lukavsky (2008) conducted a review in Hepatitis C Virus (HCV). HCV IRES domains was evaluated. HCV IRES domains function as RNA-based initiation factors to form 48S initiation complexes and 80S ribosomes with only a subset of canonical eukaryotic initiation factors.
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