Key result
Strict LBBB criteria were associated with a significant reduction in mortality compared to conventional LBBB in HFrEF patients receiving CRT (OR 0.49; 95% CI 0.24-0.99; P=0.046).
Why the study?
CRT efficacy is greater in LBBB, but whether strict LBBB criteria predict improved QRS duration and LVEF response after CRT remained unclear.
Does strict LBBB morphology predict improved QRS duration, LVEF, and mortality in HFrEF patients receiving CRT?
Cohort (n=231)
No
Does strict LBBB morphology predict improved QRS duration, LVEF, and mortality in HFrEF patients receiving CRT?
Odds Ratio: 0.49 (95% CI 0.24–0.99)
p-value: p=0.046
Strict LBBB criteria may aid CRT selection; hypothesis-generating and requires prospective validation before practice change.
BACKGROUND: Cardiac resynchronization therapy (CRT) reduces morbidity and mortality in heart failure with reduced ejection fraction (HFrEF). CRT efficacy is greater in left bundle branch block (LBBB). This study aimed to determine if strict LBBB criteria predict an improved QRS duration and left ventricular ejection fraction (LVEF) response after CRT. METHODS: HFrEF patients who received a CRT device at a single quaternary center were included. Patients were divided into three groups based on baseline QRS morphology. Group 1 consisted of patients with strict LBBB. Group 2 had conventional LBBB, and group 3 had non-LBBB morphology. Outcomes assessed included change in QRS duration after CRT, change in LVEF, and all-cause mortality. RESULTS: In 231 patients, 56% of patients were in group 1, 29% were in group 2, and 15% were in group 3. Patients with strict LBBB had a significant reduction in QRS duration (-20.9 ± 12.4 ms) compared to conventional LBBB (6.7 ± 19.4 ms; P < 0.0001) and non-LBBB (3.9 ± 29.3 ms; P < 0.0001). Patients with strict LBBB had a significant increase in LVEF (19.5 ± 10.2) compared to conventional LBBB (5.3 ± 12.6; P < 0.0001) and non-LBBB (-1.3 ± 10.9; P < 0.0001). There was moderate negative correlation between changes in QRS duration and LVEF (correlation coefficient = -0.63, P < 0.0001). Strict LBBB criteria were associated with a significant reduction in mortality compared to conventional LBBB (odds ratio 0.49, 95% confidence interval 0.24 to 0.99; P = 0.046). CONCLUSIONS: Strict LBBB predicted a reduction in QRS duration and an increase in LVEF compared to conventional LBBB and non-LBBB morphology in patients with HFrEF who received CRT.
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Hadjis et al. (2019) conducted a cohort in Heart failure with reduced ejection fraction (HFrEF) (n=231). Strict LBBB criteria vs. Conventional LBBB and non-LBBB morphology was evaluated on All-cause mortality (OR 0.49, 95% CI 0.24-0.99, p=0.046). Strict LBBB criteria were associated with a significant reduction in mortality compared to conventional LBBB in HFrEF patients receiving CRT (OR 0.49; 95% CI 0.24-0.99; P=0.046).