Key result
Aldosterone significantly induced procollagen type I synthesis in primary rat hepatic stellate cells, despite the cells lacking mineralocorticoid receptor expression.
Population
Primary and subcultured rat hepatic stellate cells
Design
Preclinical
Authors
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Aldosterone may promote collagen synthesis in rat stellate cells via non-mineralocorticoid mechanisms; leaves open relevance to human fibrosis.
Aldosterone induces modest changes in extracellular matrix synthesis in primary rat hepatic stellate cells through mechanisms independent of the mineralocorticoid receptor.
Rombouts et al. (2001) studied this question. Aldosterone was evaluated on Procollagen types I, III and IV, laminin and fibronectin synthesis. Aldosterone significantly induced procollagen type I synthesis in primary rat hepatic stellate cells, despite the cells lacking mineralocorticoid receptor expression.
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