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July 2, 2026CureusOpen Access

Early Postintubation Hemodynamic Changes Following Remimazolam or Propofol Induction With Simultaneous Bolus Remifentanil in Total Hip Arthroplasty: A Retrospective Observational Study

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Authors

NSNobuhide SasakiTSTomoharu ShakuoSMShinichiro Morotomi

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Overview

Retrospective study compares hypotension postintubation in total hip arthroplasty using remimazolam or propofol.

Key Points

  • This study aims to compare early postintubation hypotension between remimazolam and propofol during anesthesia induction.
  • Single-center retrospective study involving patients undergoing elective total hip arthroplasty.
  • Induction used standardized simultaneous-bolus protocol with remifentanil and either remimazolam or propofol.
  • Primary outcome assessed was early postintubation hypotension defined by mean arterial pressure (MAP) <65 mmHg.
  • Early postintubation hypotension occurred in 57.6% of remimazolam patients and 53.8% of propofol patients.
  • No significant difference in hypotension rates between the two groups was observed (p>0.05).
  • Older age and lower preinduction MAP were linked to increased risk of hypotension.

Cite This Study

Sasaki et al. (2026) studied this question.

synapsesocial.com/papers/6a45ff6f9ed134303130fcd3https://doi.org/10.7759/cureus.111755
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Comparison of Remimazolam and Propofol on Post-Induction Hypotension in Elderly Hypertensive Patients: A Randomized Controlled Trial2025 · 8 citations
  2. 2Hypotension after General Anesthesia Induction with Remimazolam or Propofol in Geriatric Patients Undergoing Sevoflurane Anesthesia with Remifentanil2025
  3. 3Comparison of hemodynamics during induction of general anesthesia with remimazolam and target-controlled propofol in middle-aged and elderly patients: a single-center, randomized, controlled trial2023 · 39 citations
  4. 4Comparison of hemodynamics during induction of general anesthesia with remimazolam and target-controlled propofol in middle-aged and elderly patients: A single-center, randomized, controlled trial2022 · 5 citations
  5. 5Comparison of remimazolam and propofol induction on hemodynamic response in hypertensive patients2023 · 22 citations