Key result
Pulmonary hypertension was associated with significantly higher [18F]FDG uptake in the central pulmonary artery compared to patients without the condition (median SUVR 1.17 vs 1.04, P=0.002).
Why the study?
Does [18F]FDG PET/CT imaging correlate with the severity of pulmonary hypertension in patients with end-stage pulmonary disease?
Population
109 patients with end-stage pulmonary disease being evaluated for lung transplant
Design
Cohort
Authors
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[18F]FDG PET/CT may aid noninvasive PH evaluation in end-stage lung disease; observational data leave open prospective validation before any practice change.
Cross-Sectional (n=109)
No
Does [18F]FDG PET/CT imaging correlate with the severity of pulmonary hypertension in patients with end-stage pulmonary disease?
Absolute Event Rate: 1.17% vs 1.04%
p-value: p=0.002
Thoracic [18F]FDG uptake measured by PET/CT correlates with the presence and severity of pulmonary hypertension in patients with end-stage pulmonary disease, suggesting a role for altered glucose metabolism in its pathophysiology.
Frille et al. (2016) conducted a cross-sectional in End-stage pulmonary disease with pulmonary hypertension (n=109). Pulmonary hypertension (mPAP ≥25 mm Hg) vs. No pulmonary hypertension (mPAP <25 mm Hg) was evaluated on Standardized uptake value ratio (SUVR) of [18F]FDG in the central pulmonary artery (p=0.002). Pulmonary hypertension was associated with significantly higher [18F]FDG uptake in the central pulmonary artery compared to patients without the condition (median SUVR 1.17 vs 1.04, P=0.002).
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