Key result
Left ventricular global longitudinal strain showed dominant heritability (75%) compared to ejection fraction (61%), with no differences between hypertensive and non-hypertensive subjects.
Why the study?
Does hypertension modify the genetically determined pattern of left ventricular contraction in a population of twins?
Population
92 Caucasian twin pairs (n=184 individuals), including 74 hypertensive (HTN) siblings.
Design
Cross-sectional
Authors
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Hypertension may modify heritable LV strain patterns in twins; leaves open clinical relevance for risk stratification.
Observational (n=184)
Does hypertension modify the genetically determined pattern of left ventricular contraction in a population of twins?
Effect estimate: GLS heritability 75%, EF heritability 61%
Left ventricular systolic biomechanics, particularly global longitudinal strain, are highly heritable regardless of early-stage hypertensive heart disease, whereas diastolic parameters are primarily environmentally determined.
Kovács et al. (2018) conducted an observational in Hypertension (n=184). Genetic inheritance and hypertension vs. Non-hypertensive subjects was evaluated on Heritability of left ventricular function (ejection fraction and global longitudinal strain) (GLS heritability 75%, EF heritability 61%). Left ventricular global longitudinal strain showed dominant heritability (75%) compared to ejection fraction (61%), with no differences between hypertensive and non-hypertensive subjects.
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