Key result
The developed computational model successfully reproduced the basal electrophysiological properties of human embryonic stem cell-derived cardiomyocytes and their transition from early to late developmental stages.
Population
Human embryonic stem cell derived cardiomyocytes at Early and Late stages of differentiation
Design
Preclinical
Authors
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Hypothesis-generating for hESC-CM maturation models; leaves open clinical translation pending in vivo validation.
A novel computational model successfully mimics the electrophysiological properties and maturation of human embryonic stem cell-derived cardiomyocytes, providing a tool for preliminary in silico testing.
Paci et al. (2012) studied Basic electrophysiology of human embryonic stem cell derived cardiomyocytes. Computational modeling vs. Experimental recordings was evaluated on Action potential features (APD, Vmax, MDP, DDR, F). The developed computational model successfully reproduced the basal electrophysiological properties of human embryonic stem cell-derived cardiomyocytes and their transition from early to late developmental stages.
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