Key result
Newly diagnosed, untreated hypertension was associated with significantly reduced global area strain (-29.1% vs -33.6%; P<0.0001) compared to healthy controls, indicating early functional LV changes.
Why the study?
Does real-time three-dimensional echocardiography identify early abnormalities of left ventricular structure and function in native, untreated hypertensive patients compared to healthy controls?
Population
76 subjects, comprising 38 newly diagnosed, never-treated hypertensive patients and 38 healthy controls.
Comparison
Real-time three-dimensional echocardiography… vs Healthy controls.
Design
Cross-sectional
Authors
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May detect subclinical LV dysfunction in untreated hypertension; hypothesis-generating for RT3DE strain before prospective validation.
Case-Control (n=76)
Does real-time three-dimensional echocardiography identify early abnormalities of left ventricular structure and function in native, untreated hypertensive patients compared to healthy controls?
Absolute Event Rate: -29.1% vs -33.6%
p-value: p=< 0.0001
Real-time three-dimensional echocardiography identifies early functional left ventricular changes, specifically reduced global area strain, in newly diagnosed, untreated hypertensive patients despite preserved ejection fraction.
Galderisi et al. (2012) conducted a case-control in Hypertension (n=76). Newly diagnosed, untreated hypertension vs. Healthy controls was evaluated on Global area strain (GAS) (p=< 0.0001). Newly diagnosed, untreated hypertension was associated with significantly reduced global area strain (-29.1% vs -33.6%; P<0.0001) compared to healthy controls, indicating early functional LV changes.
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