Key result
Left ventricular diastolic dysfunction was present in 72.46% of subjects with COPD across all stages, even after excluding known confounding cardiovascular risk factors.
Why the study?
Cor pulmonale alone does not fully explain refractory heart failure in COPD, possibly implicating left ventricular involvement, but prior studies did not exclude confounding factors influencing LV function.
Is left ventricular diastolic dysfunction common in patients with COPD without other confounding comorbidities?
Cross-Sectional (n=69)
No
Is left ventricular diastolic dysfunction common in patients with COPD without other confounding comorbidities?
Left ventricular diastolic dysfunction is common across all stages of COPD even in the absence of other confounding comorbidities, suggesting a potential role for routine screening echocardiography.
Chronic obstructive pulmonary disease (COPD) is the world's third leading cause of death, posing a significant public health challenge. Heart failure is an important milestone in the natural history of this disease's ever-decreasing course. Cor pulmonale alone is sometimes insufficient to explain the scenario, as many heart failures are refractory even after standard treatment. A possible explanation is the involvement of the left ventricle (LV). However, there is currently no consensus on a therapeutic approach to LV dysfunction in COPD. Some previous studies were conducted on COPD patients regardless of the presence or absence of other factors influencing LV function. This study attempted to rule out all known confounding factors/comorbidities that influence LV function. We discovered that LV diastolic dysfunction was common in subjects at all stages of COPD. We believe that all COPD patients, regardless of stage, should have screening echocardiography.
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Mupparapu et al. (2023) conducted a cross-sectional in Chronic obstructive pulmonary disease (COPD) (n=69). Chronic obstructive pulmonary disease was evaluated on Left ventricular diastolic dysfunction (LVDD). Left ventricular diastolic dysfunction was present in 72.46% of subjects with COPD across all stages, even after excluding known confounding cardiovascular risk factors.
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