Key result
Verapamil, Prenylamine, and Cinnarizine prevented or reduced the severity of heart lesions in cardiomyopathic hamsters, though they did not protect against existing skeletal muscle changes.
Why the study?
Do calcium antagonistic compounds prevent the development or reduce the severity of heart lesions in cardiomyopathic hamsters?
Do calcium antagonistic compounds prevent the development or reduce the severity of heart lesions in cardiomyopathic hamsters?
Answers are grounded in this paper and cite their sources.
Calcium antagonistic compounds like verapamil prevent or reduce the severity of heart lesions in a hamster model of hereditary cardiomyopathy, suggesting a primary defect in muscle cell membranes.
Verapamil, Prenylamine and, to a lesser extent, Cinnarizine were highly efficient in preventing the development or reducing the severity of heart lesions in cardiomyopathic hamster of the UM-X7.1 line. The calcium antagonistic compounds did not protect against the skeletal muscle changes already present at the time when treatment was initiated. The cardiac lesions were also significantly diminished in frequency and severity by a low calcium diet and in apparent contradiction, by parenteral administration of calcium gluconate. The relation of these electrolytes and creatine phosphokinase is not yet fully understood but suggests that a primary defect in muscles cell membranes may be responsible for hereditary cardiomyopathy in hamsters.
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Jasmin et al. (1975) studied Hereditary cardiomyopathy. Verapamil, Prenylamine, and Cinnarizine was evaluated on Development or severity of heart lesions. Verapamil, Prenylamine, and Cinnarizine prevented or reduced the severity of heart lesions in cardiomyopathic hamsters, though they did not protect against existing skeletal muscle changes.
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