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June 30, 2013Reviews in Cardiovascular MedicineOpen Access

Cardiometabolic Risk Factors and Atrial Fibrillation

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Key result

Cardiometabolic risk factors, including obesity, hypertension, and diabetes, are significantly associated with an increased risk of developing and recurring atrial fibrillation.

Design

Review

Authors

AMArthur R. MenezesCLCarl J. LavieJDJames J. DiNicolantonio

Discussion

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Overview

Supports MetS-AF association in existing data; leaves open causality and whether targeting components alters AF incidence.

PICO

P
Population
A review of the literature examining the association between cardiometabolic risk factors (obesity, hypertension, diabetes, dyslipidemia) and the development or recurrence of atrial fibrillation.
E
Exposure / Comparator
Cardiometabolic risk factors (Obesity, Hypertension, Diabetes, Dyslipidemia) vs Absence of cardiometabolic risk factors

This review summarizes the relationship between metabolic syndrome components and the development or pathophysiology of atrial fibrillation.

Limitations

  • The role of ACE inhibitors and ARBs in preventing AF remains controversial with conflicting study results.
  • The association between type 2 diabetes and AF, as well as statin use and AF prevention, remains controversial and subject to debate.
  • Data suggesting obesity predicts progression from paroxysmal to permanent AF are very limited.

Cite This Study

Menezes et al. (2013) conducted a review in Atrial Fibrillation and Metabolic Syndrome. Cardiometabolic risk factors (Obesity, Hypertension, Diabetes, Dyslipidemia) vs. Absence of cardiometabolic risk factors was evaluated. Cardiometabolic risk factors, including obesity, hypertension, and diabetes, are significantly associated with an increased risk of developing and recurring atrial fibrillation.

synapsesocial.com/papers/6a6184c22004386bc7d0aecdhttps://doi.org/10.3909/ricm0693
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Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Anticoagulation Strategies in Atrial Fibrillation2012 · 5 citations
  2. 2Lifetime Risk for Development of Atrial Fibrillation2004 · 2,060 citations
  3. 3Diagnosis and Management of the Metabolic Syndrome2005 · 11,930 citations
  4. 4A Prospective Study Evaluating the Role of Obesity and Obstructive Sleep Apnea for Outcomes After Catheter Ablation of Atrial Fibrillation2009 · 111 citations