Key result
A genetically clamped renin transgene in mice induced high blood pressure and kidney damage, which were reduced by losartan treatment without affecting transgene expression.
Population
Mice with a genetically clamped renin transgene
Design
Preclinical
Authors
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Supports losartan in renin-transgenic hypertension models; leaves open translation to human disease.
The creation of a genetically clamped renin transgenic mouse model provides a stable, high-renin environment to study hypertension without the confounding effects of homeostatic compensations.
Caron et al. (2002) studied Hypertension. Genetically clamped renin transgene was evaluated on Blood pressure, thirst, urine output, proteinuria, and kidney damage. A genetically clamped renin transgene in mice induced high blood pressure and kidney damage, which were reduced by losartan treatment without affecting transgene expression.
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