Key result
Fostriecin pretreatment significantly reduced myocardial infarct size to 8% of the ischemic zone compared to 33% in untreated controls (P<0.001), with protection also seen when given after ischemia onset.
Why the study?
Does fostriecin reduce infarct size in isolated rabbit hearts subjected to ischemia?
Does fostriecin reduce infarct size in isolated rabbit hearts subjected to ischemia?
Absolute Event Rate: 8% vs 33%
p-value: p=<0.001
Fostriecin limits myocardial infarct size in isolated rabbit hearts even when administered after the onset of ischemia, suggesting a protective role independent of the ischemic preconditioning mechanism.
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PP2A inhibition may confer post-ischemic cardioprotection; extends mechanistic understanding of preconditioning but leaves clinical translation open.
Weinbrenner et al. (1998) studied Myocardial infarction and ischemia. Fostriecin vs. Untreated control was evaluated on Infarct size as a percentage of the ischemic zone (p=<0.001). Fostriecin pretreatment significantly reduced myocardial infarct size to 8% of the ischemic zone compared to 33% in untreated controls (P<0.001), with protection also seen when given after ischemia onset.
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