Key result
Skeletal muscle abnormalities and ergoreflex activation in chronic heart failure contribute to increased ventilation, sympathetic activation, and symptoms of fatigue and breathlessness.
Population
Patients with chronic heart failure
Design
Review
Authors
Loading...
Muscle abnormalities may drive ergoreflex-mediated ventilatory and sympathetic excess in HF; leaves open whether myopathy-targeted interventions alter outcomes.
Skeletal myopathy and the resulting ergoreflex activation play a central role in generating the hallmark symptoms of fatigue and breathlessness in chronic heart failure.
Andrew L. Clark (2005) conducted a review in chronic heart failure. Skeletal muscle abnormalities and ergoreflex activation in chronic heart failure contribute to increased ventilation, sympathetic activation, and symptoms of fatigue and breathlessness.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: