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July 24, 2024Systematic ReviewsOpen Access

Exploring heart rate variability in polycystic ovary syndrome: implications for cardiovascular health: a systematic review and meta-analysis

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Key result

Polycystic ovary syndrome is associated with a significant decrease in heart rate variability, including a reduction in SDNN (SMD -0.763) compared to healthy controls.

Why the study?

Decreased heart rate variability is linked to adverse cardiovascular events, and recent research has suggested altered autonomic drive in PCOS, warranting evaluation of cardiac autonomic function via HRV in this population.

Does polycystic ovary syndrome reduce heart rate variability in women of reproductive age compared to healthy controls?

Comparison

PCOS vs control group

Design

Systematic review and meta-analysis

Authors

SMSeyedeh‐Tarlan MirzohrehPPPadideh PanahiFHFariba Heidari

Discussion

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Overview

May indicate elevated CV risk in PCOS; leaves open need for prospective validation before practice change.

Study Design

Type

Meta-Analysis (n=1,013)

Structured PICO

Does polycystic ovary syndrome reduce heart rate variability in women of reproductive age compared to healthy controls?

P
Population
1,013 women aged 18 and older with polycystic ovary syndrome and matched healthy controls included across 17 observational studies to evaluate cardiac autonomic function.
E
Exposure
Polycystic ovary syndrome (PCOS) diagnosis
C
Comparator
Appropriately matched healthy women without PCOS
O
Outcome
Heart rate variability (HRV) indices, including time-domain (e.g., SDNN, RMSSD, PNN50) and frequency-domain (e.g., LF, HF, LF/HF ratio, TP) measuressurrogate

Main Result

Standardized Mean Difference: -0.763 (95% CI -1.289–-0.237)

p-value: p=0.004

Women with polycystic ovary syndrome exhibit diminished heart rate variability compared to healthy controls, suggesting impaired cardiac autonomic function that may contribute to increased cardiovascular risk.

Limitations

  • High heterogeneity among included studies
  • Inherent susceptibility to bias in observational studies
  • Potential bias in the selection and diagnosis of PCOS cases
  • Reporting bias arising from the limited diversity in the countries of origin for the included studies
  • Susceptibility to bias in observational studies
  • Substantial heterogeneity

Cite This Study

Mirzohreh et al. (2024) conducted a meta-analysis in Polycystic ovary syndrome (PCOS) (n=1,013). Polycystic ovary syndrome vs. Non-PCOS control group was evaluated on Standard deviation of normal-to-normal intervals (SDNN) (SMD -0.763, 95% CI -1.289 to -0.237, p=0.004). Polycystic ovary syndrome is associated with a significant decrease in heart rate variability, including a reduction in SDNN (SMD -0.763) compared to healthy controls.

synapsesocial.com/papers/6a63b2b51ec0c1a689b7103chttps://doi.org/10.1186/s13643-024-02617-x
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Analysis of heart rate variability in polycystic ovary syndrome2010 · 55 citations
  2. 2Heart Rate Variability in Young Women with Polycystic Ovary Syndrome2006 · 113 citations
  3. 3Autonomic dysfunction and resting heart rate abnormalities as early cardiovascular signals in polycystic ovary syndrome (PCOS): a focused review2026
  4. 4Heart rate variability in normal-weight patients with polycystic ovary syndrome2017 · 15 citations
  5. 5Characteristics of heart rate variability in women with polycystic ovary syndrome2018 · 27 citations