Key result
Normal-weight women with PCOS and normal insulin resistance show similar HRV to healthy controls.
Why the study?
The cardiac autonomic functions of normal-weight women with PCOS are conflicting and need assessment of cardiac sympathovagal balance reactivity.
Does polycystic ovary syndrome alter cardiac sympathovagal balance and heart rate variability in normal-weight women?
Case-Control (n=120)
Does polycystic ovary syndrome alter cardiac sympathovagal balance and heart rate variability in normal-weight women?
Normal-weight women with PCOS and normal insulin resistance do not exhibit altered cardiac sympathovagal balance compared to healthy controls.
Answers are grounded in this paper and cite their sources.
Preserved HRV reactivity in normal-weight PCOS with normal HOMA-IR; leaves open whether obesity or insulin resistance drives autonomic changes reported elsewhere.
OBJECTIVE: Polycystic ovary syndrome (PCOS) is an endocrine disease closely related to several risk factors of cardiovascular disease. Obese women with PCOS show altered autonomic modulation. The results of studies investigating cardiac autonomic functions of normal-weight women with PCOS are conflicting. The aim of the study was to assess the reactivity of cardiac sympathovagal balance in normal-weight women with PCOS by heart rate variability analysis. METHODS: We examined the heart rate variability in 60 normal-weight women with PCOS and compared them with that in 60 age-matched healthy women having a similar metabolic profile. Time and frequency domain parameters of heart rate variability were analyzed based on 5-min-long continuous electrocardiography recordings for the following 3 periods: (1) during rest in supine position, (2) during controlled breathing, and (3) during isometric handgrip exercise. RESULTS: Time and frequency domain parameters of heart rate variability for the 3 periods assessed were similar in the two groups. Although modified Ferriman-Gallwey score and serum testosterone and luteinizing hormone levels were significantly higher in women with PCOS, homeostatic model assessment-insulin resistance (HOMA-IR) was not different the between the PCOS and control groups. There were no significant correlations between serum testosterone levels and heart rate variability parameters among the study population. CONCLUSION: The findings of this study suggest that the reactivity of cardiac sympathovagal balance is not altered in normal-weight women with PCOS having a normal HOMA-IR.
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Celal Kılıt (2017) conducted a case-control in Polycystic ovary syndrome (n=120). Polycystic ovary syndrome vs. Age-matched healthy women was evaluated on Time and frequency domain parameters of heart rate variability during rest, controlled breathing, and isometric handgrip exercise. Normal-weight women with polycystic ovary syndrome and normal insulin resistance had similar time and frequency domain parameters of heart rate variability compared to healthy controls.
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